![]() Here, using in vivo live imaging, we demonstrate the zebrafish thyroid follicular cells (TFCs) are ciliated, polarized and surrounded by a network of blood and lymphatic vessels. Moreover, 84 per cent of genes known to be associated with human disease have a zebrafish counterpart, allowing modeling of human disorders. Zebrafish provide the advantage of transparency during early development, allowing direct visualization of thyroid morphogenesis and growth. ![]() To elucidate the fundamental processes regulating thyroid physiology, we harness a genetically tractable vertebrate model system, the zebrafish. And it does so by utilizing a structure that is conserved among vertebrates: a follicle composed of epithelial tissue with a central lumen for storage of iodinated molecules. ![]() In the simplest form, the vertebrate thyroid gland is an iodine accumulating organ.
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